ERAB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-75460

Novus Biologicals, part of Bio-Techne
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NB100-75460
NB100-75460-0.025mg
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Chicken

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ERAB Antibodies »

Product Specifications

Immunogen

The immunogen for this antibody was a sequence from 57a.a. to 314a.a. from ERAB(a 314a.a. long protein)

Reactivity Notes

This antibody is reactive against Human, mouse, rat.

Localization

Mitochondrial

Specificity

ERAB

Clonality

Polyclonal

Host

Chicken

Scientific Data Images for ERAB Antibody

Western Blot: ERAB Antibody [NB100-75460]

Western Blot: ERAB Antibody [NB100-75460]

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-HADHSC )

Applications for ERAB Antibody

Application
Recommended Usage

Western Blot

1:200 - 1:500
Application Notes
Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000. Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2)

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ERAB

ERAB is a member of the short-chain dehydrogenase/reductase superfamily. This mitochondrial protein catalyzes the oxidation of a wide variety of fatty acids, alcohols, and steroids. It has been implicated in the development of Alzheimer's disease, and mutations in the gene are the cause of 2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency (MHBD, a disorder characterized by neurological abnormalities, including psychomotor retardation and loss of mental and motor skills). Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined. Abundant in human liver, kidney and gonads, but it is present in only negligible amounts in skeletal muscle. At the sub-cellular level, in normal tissues, this protein is located in mithocondria. It is over-expressed in Neurons of patients with Alzheimer's disease.

Alternate Names

17-beta-HSD 10, 17-beta-hydroxysteroid dehydrogenase 10, 17b-HSD10, 3-hydroxy-2-methylbutyryl-CoA dehydrogenase, ABAD, amyloid-beta peptide binding alcohol dehydrogenase, CAMR, DUPXp11.22, EC 1.1.1.178, EC 1.1.1.35, Endoplasmic reticulum-associated amyloid beta-peptide-binding protein, ERAB3-hydroxyacyl-CoA dehydrogenase type-2, HADH2AB-binding alcohol dehydrogenase, hydroxyacyl-Coenzyme A dehydrogenase, type II, hydroxyacyl-Coenzyme Adehydrogenase, type II, hydroxysteroid (17-beta) dehydrogenase 10, mental retardation, X-linked, syndromic 10, MHBD, Mitochondrial ribonuclease P protein 2,3-hydroxyacyl-CoA dehydrogenase type II, Mitochondrial RNase P protein 2, MRPP2HCD2, MRX17, MRX31, MRXS10, SCHAD, SDR5C1, short chain dehydrogenase/reductase family 5C, member 1, short chain L-3-hydroxyacyl-CoA dehydrogenase type 2, short chain type dehydrogenase/reductase XH98G2, Short-chain type dehydrogenase/reductase XH98G2, Type II HADH, XH98G2

Entrez Gene IDs

3028 (Human); 15107 (Mouse); 113965 (Rat)

Gene Symbol

HSD17B10

UniProt

Q16836 (Human)

Additional ERAB Products

Product Documents for ERAB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for ERAB Antibody

Chicken products cannot be exported to Canada.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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