ErbB2/Her2 Antibody (24D2) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-09136

Clone 24D2 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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NBP3-09136
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 24D2

Format

BSA Free

Concentration

1 mg/ml

View all ErbB2/Her2 Antibodies »

Product Specifications

Immunogen

NIH-3T3/huErbB2/Her2 cells

Specificity

The mouse monoclonal antibody 24D2 recognizes an extracellular epitope of human CD340 (HER-2), a type I transmembrane protein expressed by mesenchymal stem cells, B-lymphoblastic leukemia cells, subsets of C-ALL blasts, and and various types of carcinomas.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for ErbB2/Her2 Antibody (24D2) - BSA Free

Flow Cytometry: ErbB2/Her2 Antibody (24D2) - BSA Free [NBP3-09136]

Flow Cytometry: ErbB2/Her2 Antibody (24D2) - BSA Free [NBP3-09136]

Flow Cytometry: ErbB2/Her2 Antibody (24D2) [NBP3-09136] - Separation of MCF-7 cells stained using anti-human CD340 (24D2) purified antibody (concentration in sample 5,0 ug/ml, GAM APC, red-filled) from MCF-7 cells unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Applications for ErbB2/Her2 Antibody (24D2) - BSA Free

Application
Recommended Usage

Flow Cytometry

1-4 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ErbB2/Her2

ErbB2/HER2 is one of the four members of the ErbB receptor family of transmembrane receptor-like tyrosine kinases (1). The kinase activity of ErbB2 can be activated without ligand if it is overexpressed, and by association with other ErbB proteins (2). Overexpression of ErbB2 is detected in almost 40% of human breast cancers (3). Binding of c-Cbl ubiquitin ligase to Tyr1112 of ErbB2 leads to poly-ubiquitination of ErbB2 and enhances its degradation (4). ErbB2 is one of the major targets for the treatment of breast cancer and other carcinomas.

Long Name

Receptor Tyrosine Protein Kinase ErbB2

Alternate Names

CD340, HER2, Neu Oncogene, NGL, TKR1

Gene Symbol

ERBB2

Additional ErbB2/Her2 Products

Product Documents for ErbB2/Her2 Antibody (24D2) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ErbB2/Her2 Antibody (24D2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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