ErbB4/Her4 Antibody (8E5D0)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15632

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15632-100ul
NBP3-15632-20ul
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 8E5D0

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ErbB4/Her4 Antibodies »

Product Summary for ErbB4/Her4 Antibody (8E5D0)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1200-1308 of human ErbB4/HER4 (Q15303). DEYVNEPLYLNTFANTLGKAEYLKNNILSMPEKAKKAFDNPDYWNHSLPPRSTLQHPDYLQEYSTKYFYKQNGRIRPIVAENPEYLSEFSLKPGTVLPPPPYRHRNTVV

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ErbB4/Her4 Antibody (8E5D0)

Western Blot: ErbB4/Her4 Antibody (8E5D0) [NBP3-15632]

Western Blot: ErbB4/Her4 Antibody (8E5D0) [NBP3-15632]

Western Blot: ErbB4/Her4 Antibody (8E5D0) [NBP3-15632] - Western blot analysis of extracts of various cell lines, using ErbB4/Her4 antibody (NBP3-15632) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Applications for ErbB4/Her4 Antibody (8E5D0)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ErbB4/Her4

erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Long Name

Receptor Tyrosine Protein Kinase ErbB4

Alternate Names

HER4

Gene Symbol

ERBB4

Additional ErbB4/Her4 Products

Product Documents for ErbB4/Her4 Antibody (8E5D0)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ErbB4/Her4 Antibody (8E5D0)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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