ErbB4/Her4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90371

Novus Biologicals, part of Bio-Techne
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NBP1-90371
NBP1-90371-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (91%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ErbB4/Her4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LPSPNDSKFFQNLLDEEDLEDMMDAEEYLVPQAFNIPPPIYTSRARIDSNRNQFVYRDGGFAAEQGVSVPYRAPTSTIPEAPVAQGATAEIFDDSCCNGTLRK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ErbB4/Her4 Antibody

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371] - Staining in human testis and liver tissues using anti-ERBB4 antibody. Corresponding ERBB4 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371] - Staining of human testis shows high expression.
Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371]

Immunohistochemistry-Paraffin: ErbB4/Her4 Antibody [NBP1-90371] - Staining of human liver shows low expression as expected.

Applications for ErbB4/Her4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ErbB4/Her4

erbB4/HER4 is a receptor tyrosine kinase that belongs to the human epidermal growth factor receptor (EGFR) family. erbB4/HER4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum (1). erbB4/HER4 is activated by neuregulins (NRG), betacellulin (BTC), and heparin-binding EGF-like growth factor (2). Neuregulins regulate the expression of ligand- and voltage-gated channels in neurons and skeletal muscle by the activation of ErbB 1-4. The erbB4/HER4 receptor is unique among these receptors because its C-terminal tail binds to a protein motif known as the PDZ domain (3).

Long Name

Receptor Tyrosine Protein Kinase ErbB4

Alternate Names

HER4

Entrez Gene IDs

2066 (Human)

Gene Symbol

ERBB4

UniProt

Q15303

Additional ErbB4/Her4 Products

Product Documents for ErbB4/Her4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ErbB4/Her4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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