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ERN2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-20914

Novus Biologicals, part of Bio-Techne
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NBP1-20914

Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

Product Specifications

Immunogen

Peptide with sequence C-QKRLQSPSKQAQPLD corresponding to internal region according to NP_150296.3.

Epitope

C terminus

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Description

Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.

Applications for ERN2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000
Application Notes
WB: Preliminary experiments gave an approx. 37 kDa band in human duodenum, pancreas and placenta lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 107 kDa band according to NP_150296.3. The 37 kDa band was successfully blocked by incubation with the immunizing peptide.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: ERN2

Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins

Alternate Names

EC 2.7.11, endoplasmic reticulum to nucleus signaling 2, endoplasmic reticulum to nucleus signalling 2, Endoplasmic reticulum-to-nucleus signaling 2, ER to nucleus signalling 2, hIRE2p, inositol-requiring 1 beta, Inositol-requiring protein 2, IRE1, S. cerevisiae, homolog of, IRE1-BETA, IRE1bIRE1 beta, IRE2, serine/threonine-protein kinase/endoribonuclease IRE2

Entrez Gene IDs

10595 (Human)

Gene Symbol

ERN2

Additional ERN2 Products

Product Documents for ERN2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ERN2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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