ERR beta/NR3B2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21375

Novus Biologicals, part of Bio-Techne
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NBP3-21375-100ul
NBP3-21375-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (93%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ERR beta/NR3B2 Antibodies »

Product Summary for ERR beta/NR3B2 Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SGSSDASGGFGLALGTHANGLDSPPMFAGA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ERR beta/NR3B2 Antibody

Immunocytochemistry/Immunofluorescence: ERR beta/NR3B2 Antibody [NBP3-21375] -

Immunocytochemistry/Immunofluorescence: ERR beta/NR3B2 Antibody [NBP3-21375] -

Staining of human cell line K-562 shows localization to nucleoplasm & cytosol.

Applications for ERR beta/NR3B2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ERR beta/NR3B2

Estrogen-related receptor beta (ERR beta) a NR3 Steroid Receptor, has been shown to affect early placental development. ERR beta also can act as a repressor of transcriptional activity mediated by the glucocorticoid receptor (GR). ERR beta binds as a monomer to the extended half-site TNAAGTGCA and as a homodimer to the estrogen response element (ERE), palindromic thyroid hormone response element (TRE(pal)), and SF-1 response element, but not to the glucocorticoid response element (GRE). ERR beta mutations lead to abnormal development of the chorion and defective diploid trophoblast proliferation, and are lethal during midgestation. ERR beta expression has been documented in mice in the extraembryonic ectoderm that gives rise to the chorion. ESTs have been isolated from normal human eye, lung, and testis libraries.

Long Name

Estrogen-related Receptor beta

Alternate Names

ERR2, ESRL2, ESRRB, NR3B2

Gene Symbol

ESRRB

Additional ERR beta/NR3B2 Products

Product Documents for ERR beta/NR3B2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for ERR beta/NR3B2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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