Factor XIIIa Antibody (S06-3A7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19500

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19500-100ul
NBP3-19500-50ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S06-3A7

Concentration

0.3 mg/ml

View all F13A1 Antibodies »

Product Specifications

Immunogen

Recombinant protein of human Factor XIIIa (Uniprot # P00488)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

83 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Factor XIIIa Antibody (S06-3A7)

Western Blot: Factor XIIIa Antibody (S06-3A7) [NBP3-19500]

Western Blot: Factor XIIIa Antibody (S06-3A7) [NBP3-19500]

Western Blot: Factor XIIIa Antibody (S06-3A7) [NBP3-19500] - Western blot detection of Factor XIIIa in Jurkat cell lysates using NBP3-19500 (1:1000 diluted). Predicted band size: 83kDa. Observed band size: 83kDa.
Immunohistochemistry-Paraffin: Factor XIIIa Antibody (S06-3A7) [NBP3-19500]

Immunohistochemistry-Paraffin: Factor XIIIa Antibody (S06-3A7) [NBP3-19500]

Immunohistochemistry-Paraffin: Factor XIIIa Antibody (S06-3A7) [NBP3-19500] - Immunohistochemistry of Factor XIIIa in paraffin-embedded Human colon cancer tissue using NBP3-19500 at dilution 1/100

Applications for Factor XIIIa Antibody (S06-3A7)

Application
Recommended Usage

Immunohistochemistry

1/50

Western Blot

1/2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: F13A1

Factor XIII is a beta globulin found in plasma and is composed of two subunits. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Factor XIII A is the catalytic subunit and is a dimmer of molecular weight 160kDa. The B subunits do not have enzymatic activity and may serve as a plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon activation by the cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIII A, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. Factor XIII A is a dermal dendrocyte marker and shows variable reaction with these types of tumors. It can be used for histiocytic phenotyping and has been reported to mark capillary hemangiomas and tumors of the central nervous system.

Long Name

Coagulation Factor XIII, A1 Polypeptide

Alternate Names

F13A, FSF, A Subunit

Gene Symbol

F13A1

Additional F13A1 Products

Product Documents for Factor XIIIa Antibody (S06-3A7)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Factor XIIIa Antibody (S06-3A7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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