FADD Antibody (S05-1K1)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19630

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-19630-50ul
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Key Product Details

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-1K1

Concentration

0.3 mg/ml

View all FADD Antibodies »

Product Specifications

Immunogen

A synthetic peptide of mouse FADD (Uniprot # Q61160)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

28 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FADD Antibody (S05-1K1)

Western Blot: FADD Antibody (S05-1K1) [NBP3-19630]

Western Blot: FADD Antibody (S05-1K1) [NBP3-19630]

Western Blot: FADD Antibody (S05-1K1) [NBP3-19630] - Western blot detection of FADD in SHSY-5Y cell lysates using NBP3-19630 (1:1000 diluted). Predicted band size: 23KDa. Observed band size: 28KDa.

Applications for FADD Antibody (S05-1K1)

Application
Recommended Usage

Western Blot

1/1000-1/5000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FADD

Fas-associating protein with death domain (FADD) is an adaptor protein involved in the apoptosis induced by Fas and TNF-R1, and mitogen induced cell proliferation (1). FADD consists of death domain (DD) at the C-terminal and death effector domain (DED) at the N-terminal (2). DD interacts with Fas and TNF-R1, which exposes the DED portion on the FADD. Unmasked DED binds to the DED of pro-caspase-8, which activates the cysteine protease cascade (3). The development of autoimmune lymphoproliferative (lpr) diseases has been linked to inactivation of Fas-FADD interaction (4). Also, the deficiency in FADD can inhibit TRAIL-induced cell apoptosis.

Long Name

Fas-associated Death Domain Protein

Alternate Names

MORT1

Gene Symbol

FADD

Additional FADD Products

Product Documents for FADD Antibody (S05-1K1)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FADD Antibody (S05-1K1)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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