FANCC Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-2565

Novus Biologicals, part of Bio-Techne
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NB100-2565
NB100-2565SS
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (92%). Backed by our 100% Guarantee.

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all FANCC Antibodies »

Product Specifications

Immunogen

A C-terminal peptide within residues 450-558 of human FANCC. [SwissProt# Q00597]

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: rat (92%), mouse (92%) and bovine (81%).

Localization

The major form is nuclear. The minor form is cytoplasmic.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

65 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for FANCC Antibody

Western Blot: FANCC Antibody [NB100-2565]

Western Blot: FANCC Antibody [NB100-2565]

Western Blot: FANCC Antibody [NB100-2565] - Detection of FANC C in transfected COS1 cell lysate.

Applications for FANCC Antibody

Application
Recommended Usage

Western Blot

1:1000
Application Notes
This FANCC antibody is useful for Western Blot where a band is seen at approximately 65 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: FANCC

FANCC (Fanconi anemia group C protein) is a DNA repair protein which implicates in post-replication DNA repair or a cell cycle checkpoint function. FANCC also involves in the interstrand DNA cross-link repair as well as the maintenance of chromosome stability/integrity. FANCC participates in the multisubunit FA complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and HSP70) which is not found in FA patients. Upon IFNG induction, FANCC facilitate STAT1 activation via recruitement of STAT1 to IFNGR1. FANCC interacts with ZBTB32 (upon IFNG induction), CDK1, STAT1 etc and FANCC-EIF2AK2 interactions leads to augmented EIF2AK2 activation and cell death. FANCC is expressed ubiquitously and the major form is nuclear while the minor form is cytoplasmic. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC), disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.

Long Name

Fanconi Anemia Complementation Group C

Alternate Names

FA Complementation Group C, FA3, FACC

Entrez Gene IDs

2176 (Human); 14088 (Mouse); 24361 (Rat)

Gene Symbol

FANCC

UniProt

Q00597 (Human)

Additional FANCC Products

Product Documents for FANCC Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FANCC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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