Fc epsilon RI Antibody (IB10) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12049

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-12049-0.025mg
NBP3-12049-0.2mg
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Block/Neutralize, Flow Cytometry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Mouse IgG1 kappa Clone # IB10

Format

Azide and BSA Free

Concentration

1 mg/ml

View all Fc epsilon RI Antibodies »

Product Summary for Fc epsilon RI Antibody (IB10) - Azide and BSA Free

Immunogen

Recombinant human protein, N-terminus.

Specificity

This antibody binds to human Fc epsilon receptor and competes with IgE binding.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Applications for Fc epsilon RI Antibody (IB10) - Azide and BSA Free

Application
Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
IB10 competes with IgE for binding to human FCER1A; consequently, its binding to mast cells and basophils is decreased when IgE concentration is high, but it does block IgE binding to these cells. IB10 and IE7 do not crossblock each other's binding.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

Azide and BSA Free

Preservative

0.02% Proclin 300

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.

Background: Fc epsilon RI

The allergic reaction is mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FceRI receptor is a tetrameric complex, consisting of a a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

Alternate Names

alpha polypeptide, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, Fc-epsilon RI-alpha, FcERI, high affinity immunoglobulin epsilon receptor alpha-subunit, high affinity immunoglobulin epsilon receptor subunit alpha, high-affinity, of mast cells, alpha polypeptide

Gene Symbol

FCER1A

Additional Fc epsilon RI Products

Product Documents for Fc epsilon RI Antibody (IB10) - Azide and BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Fc epsilon RI Antibody (IB10) - Azide and BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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