Fc epsilon RI Antibody (IB10) [Janelia Fluor® 549]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12050JF549

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-12050JF549
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Block/Neutralize, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

Janelia Fluor 549

Antibody Source

Monoclonal Rabbit IgG Kappa Clone # IB10

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Fc epsilon RI Antibodies »

Product Summary for Fc epsilon RI Antibody (IB10) [Janelia Fluor® 549]

Immunogen

Recombinant human protein, N-terminus.

Specificity

This antibody binds to human Fc epsilon receptor and competes with IgE binding.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for Fc epsilon RI Antibody (IB10) [Janelia Fluor® 549]

Application
Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Fc epsilon RI

The allergic reaction is mediated through the IgE high affinity receptor (FceRI). When a multivalent antigen is presented, a redistribution of the monomeric IgE FceRI receptor complexes cause the degranulation of mast cells and basophils, resulting in the subsequent release of factors responsible for the allergic reaction. The FceRI receptor is a tetrameric complex, consisting of a a-chain, b-chain and a dimeric g-chain. While the a-chain is primarily involved with the binding of IgE, the signal is transferred through the g subunit, which contains the immunoreceptor tyrosine activation motifs (ITAM) critical for initiating receptor mediated signal transduction through the Syk and Lyn tyrosine kinases. The FceRI receptor is able to engage and disengage the IgE, providing a versatile model for studying the function of kinase coupled receptors.

Alternate Names

alpha polypeptide, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide, Fc-epsilon RI-alpha, FcERI, high affinity immunoglobulin epsilon receptor alpha-subunit, high affinity immunoglobulin epsilon receptor subunit alpha, high-affinity, of mast cells, alpha polypeptide

Gene Symbol

FCER1A

Additional Fc epsilon RI Products

Product Documents for Fc epsilon RI Antibody (IB10) [Janelia Fluor® 549]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Fc epsilon RI Antibody (IB10) [Janelia Fluor® 549]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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