Fc gamma RII/RIII (CD32/CD16) Antibody (2.4G2) [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-52644JF646

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Mouse

Applications

Block/Neutralize, CyTOF-ready, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunoprecipitation

Label

Janelia Fluor 646

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # 2.4G2

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Fc gamma RII/RIII (CD32/CD16) Antibodies »

Product Specifications

Immunogen

Mouse BALB/c Macrophage J774 Cell Line.

Reactivity Notes

Mouse

Specificity

This antibody binds to an epitope on the extracellular domains of the mouse Fc(gamma)III and Fc(gamma)II, thereby inhibiting their ability to bind antibodies via their Fc region. receptors. Also binding the Fc(gamma)I receptor (CD64) via its Fc domain.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for Fc gamma RII/RIII (CD32/CD16) Antibody (2.4G2) [Janelia Fluor® 646]

Application
Recommended Usage

Block/Neutralize

Optimal dilutions of this antibody should be experimentally determined.

CyTOF-ready

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: Fc gamma RII/RIII (CD32/CD16)

Receptors that recognize the Fc portion of IgG are divided into three groups designated Fc gamma RI, RII, and RIII, also known respectively as CD64, CD32, and CD16. In humans each group of receptors is encoded by 2 - 3 closely related genes designated A, B, and C. Fc gamma RI binds IgG with high affinity and functions during early immune responses. Fc gamma RII and RIII are low affinity receptors that recognize IgG as aggregates surrounding multivalent antigens during late immune responses. Different Fc receptors can function as activators, as inhibitors, or as decoy receptors.

Long Name

Fc gamma Receptor II/III

Alternate Names

CD32/CD16

Gene Symbol

FCGR3A

Additional Fc gamma RII/RIII (CD32/CD16) Products

Product Documents

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Fc gamma RII/RIII (CD32/CD16) Antibody (2.4G2) [Janelia Fluor® 646]



Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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