FDC Antibody (CNA.42)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-43118

Novus Biologicals, part of Bio-Techne
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NBP1-43118-0.025mg
NBP1-43118-0.1mg
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Key Product Details

Species Reactivity

Human

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgM Clone # CNA.42

Concentration

0.5 mg/ml

View all FDC Antibodies »

Product Specifications

Immunogen

The immunogen for this antibody was follicular dendritic cells.

Clonality

Monoclonal

Host

Mouse

Isotype

IgM

Scientific Data Images for FDC Antibody (CNA.42)

Immunohistochemistry-Paraffin: FDC Antibody (CNA.42) [NBP1-43118]

Immunohistochemistry-Paraffin: FDC Antibody (CNA.42) [NBP1-43118]

Immunohistochemistry-Paraffin: FDC Antibody (CNA.42) [NBP1-43118] - Formalin-fixed paraffin embedded human tonsil using 1 ug/mL Mouse IgM Isotype Control (left) or 1 ug/mL Anti-Human FDC Purified (right) followed by anti-Mouse IgG Biotin and DAB visualization. Nuclei are counterstained with hematoxylin.

Applications for FDC Antibody (CNA.42)

Application
Recommended Usage

Flow Cytometry

1:10-1:1000

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Frozen

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Western Blot

1:100-1:2000
Application Notes
This CNA.42 antibody has been tested by flow cytometric of human cell line and western blotting. This can be used at less than or equal to 0.5 ug per million cells in a 100 ul total staining volume or 2ug/ml (for western blotting).

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2)

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: FDC

The monoclonal antibody CNA.42 recognizes a unique carbohydrate epitope found on follicular dendritic cells (FDCs) from a variety of species. FDCs are large cells in germinal centers (GCs) of primary and lymphoid tissues. They present non-processed antigen and switch off apoptosis of B cells through a selection process resulting in selection of memory B cells. FDCs express many B cell markers such as CD21 (long isoform), CD23 and CD35. A role for FDCs as been shown in various infectious diseases such as AIDS and transmissible spongiform encephalitis. Staining with this CNA.42 monoclonal antibody is mainly restricted to the plasma membrane but in limited cases may also be cytoplasmic (as seen in mast cells). This monoclonal has been shown to be a useful reagent for both flow cytometry and IHC analysis.

Alternate Names

cardiomyopathy, dilated 1B (autosomal dominant), CMPD1, FDC

Gene Symbol

CMD1B

Additional FDC Products

Product Documents for FDC Antibody (CNA.42)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FDC Antibody (CNA.42)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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