FEM1B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86219

Novus Biologicals, part of Bio-Techne
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NBP1-86219
NBP1-86219-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (97%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all FEM1B Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RFAQVFSQMIHLNETVKAPDIECVLRCSVLEIEQSMNRVKNISDADVHNAMDNYECNLYTFLYLVCISTKTQCSEEDQCKINKQIYNLIH

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FEM1B Antibody

Western Blot: FEM1B Antibody [NBP1-86219]

Western Blot: FEM1B Antibody [NBP1-86219]

Western Blot: FEM1B Antibody [NBP1-86219] - Analysis in control (vector only transfected HEK293T lysate) and FEM1B over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).
FEM1B Antibody

Immunohistochemistry-Paraffin: FEM1B Antibody [NBP1-86219] -

Immunohistochemistry-Paraffin: FEM1B Antibody [NBP1-86219] -Staining of human testis shows moderate cytoplasmic/membranous positivity in cells in seminiferous ducts and leydig cells.
FEM1B Antibody

Immunohistochemistry-Paraffin: FEM1B Antibody [NBP1-86219] -

Immunohistochemistry-Paraffin: FEM1B Antibody [NBP1-86219] -Staining of human endometrium shows moderate cytoplasmic positivity in glandular cells.
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Applications for FEM1B Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FEM1B

Fas and tumor necrosis factor receptor 1 (TNFR1) are two prototype members in the death receptor family. A novel protein that associates with the intracellular domains of Fas and TNFR1 was recently identified and designated F1Aa and FEM1b (1,2). F1Aa/FEM1b is the homologue of C. elegans sex determining protein FEM-1. FEM-1/F1Aa is cleaved by CED-3 and caspase (3). FEM-1/F1Aa associates with CED-4 and its mammalian homologue Apaf-1 (3). Overexpression of F1Aa induces apoptosis. F1Aa is therefore a novel member of the death receptor associated protein that mediates apoptosis. F1Aa is expressed in a variety of human and mouse tissues.

Alternate Names

DKFZp451E0710, F1AA, F1A-alpha, FEM-1 (C.elegans) homolog b, fem-1 homolog b (C. elegans), FEM1b, FEM1-beta, FEM-1-like death receptor binding protein, Fem-1-like death receptor-binding protein alpha, Fem-1-like in apoptotic pathway protein alpha, FIAA, KIAA0396, protein fem-1 homolog B

Gene Symbol

FEM1B

Additional FEM1B Products

Product Documents for FEM1B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for FEM1B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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