Ficolin-2 Antibody (GN4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11232

Novus Biologicals, part of Bio-Techne
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NBP3-11232
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Applications

Immunoassay, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # GN4

Concentration

0.1 mg/ml

View all Ficolin-2 Antibodies »

Product Summary for Ficolin-2 Antibody (GN4)

Immunogen

The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Ficolin-2 Antibody (GN4)

Application
Recommended Usage

Immunoassay

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Frozen

Optimal dilutions of this antibody should be experimentally determined.

Immunoprecipitation

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Ficolin-2

The monoclonal antibody GN4 recognizes human Ficolin-2, also known as L-ficolin. Ficolins are a family of pattern recognition molecules containing both a collagen-like domain and a fibrinogen-like domain that are capable of activating the complement system, through association with MASPs, on the surface of microorganisms. In human, three Ficolins are known: Ficolin-1 (M-ficolin), Ficolin-2 (L-ficolin), and Ficolin-3 (H-ficolin). Ficolin-1, is mainly expressed by monocytes, granulocytes and lung cells and is present locally in areas of inflammation. Ficolin-2 (also L-ficolin, ficolin L, EBP-37 or hucolin) is produced primarily by the liver. The association between Ficolin-2 and MASPs/sMAP is Ca2+-dependent. MASPs in Ficolin-2-MASP complexes have proteolytic activities for C4, C2 and C3. Ficolin-2 also shows opsonic activity.

Long Name

Ficolin [Collagen/Fibrinogen Domain Containing] 2

Alternate Names

FCN2, FCNL, Ficolin2, Hucolin, L-Ficolin

Gene Symbol

FCN2

Additional Ficolin-2 Products

Product Documents for Ficolin-2 Antibody (GN4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Ficolin-2 Antibody (GN4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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