FKBP52/FKBP4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-68237

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NB100-68237
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Validated by

Independent Antibodies, Biological Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.2 mg/ml

View all FKBP52 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 400 and 440 human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FKBP52/FKBP4 Antibody

Western Blot: FKBP52/FKBP4 Antibody [NB100-68237]

Western Blot: FKBP52/FKBP4 Antibody [NB100-68237]

Western Blot: FKBP52/FKBP4 Antibody [NB100-68237] - Western Blot and Immunoprecipitation: FKBP4/FKBP52 Antibody NB100-68237 -Detection of Human FKBP4/FKBP52 on HeLa whole cell lysate (5, 15, and 50 microgram) and 293T cell lysate (50 microgram) using NB100-68237. FKBP4/FKBP52 was also immunoprecipitated by rabbit anti-FKBP4/FKBP52 antibody NB100-68236 and NB100-68238.
Immunohistochemistry: FKBP52/FKBP4 Antibody [NB100-68237]

Immunohistochemistry: FKBP52/FKBP4 Antibody [NB100-68237]

Immunohistochemistry: FKBP52/FKBP4 Antibody [NB100-68237] - Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-FKBP4/FKBP52 used at a dilution of 1:1,000 (0.2ug/ml). Detection: DAB

Applications for FKBP52/FKBP4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

1:10-1:500

Immunoprecipitation

2-5 ug/mg lysate

Western Blot

1:2000-1:10000
Application Notes
Epitope retrieval with citrate buffer pH6.0 is recommended for FFPE tissue sections.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

TBS and 0.1% BSA

Preservative

0.09% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: FKBP52

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It has high structural and functional similarity to FK506-binding protein 1A (FKBP1A), but unlike FKBP1A, this protein does not have immunosuppressant activity when complexed with FK506. It interacts with interferon regulatory factor-4 and plays an important role in immunoregulatory gene expression in B and T lymphocytes. This encoded protein is known to associate with phytanoyl-CoA alpha-hydroxylase. It can also associate with two heat shock proteins (hsp90 and hsp70) and thus may play a role in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. This protein correlates strongly with adeno-associated virus type 2 vectors (AAV) resulting in a significant increase in AAV-mediated transgene expression in human cell lines. Thus this encoded protein is thought to have important implications for the optimal use of AAV vectors in human gene therapy. This gene has been found to have multiple polyadenylation sites.

Long Name

52 kDa FK506 Binding Protein

Alternate Names

FKBP4, FKBP59, HBI, Hsp56

Entrez Gene IDs

2288 (Human)

Gene Symbol

FKBP4

UniProt

NP_002005.1 (Human)

Additional FKBP52 Products

Product Documents for FKBP52/FKBP4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for FKBP52/FKBP4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.