FNTA Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56500

Novus Biologicals, part of Bio-Techne
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NB100-56500
NB100-56500SS
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Canine, Chicken, Primate

Predicted:

Mouse (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all FNTA Antibodies »

Product Specifications

Immunogen

A portion of amino acids 150-250 of human farnesyltransferase was used as the immunogen.

Reactivity Notes

Cross reacts with Chimpanzee. Predicted to cross react with Mouse.

Specificity

The amino acid sequence used as immunogen is 100% homologous in human (isoforms CRA_a, _b, _c) and chimp (isoforms 1, 2, 3)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FNTA Antibody

Western Blot: FNTA Antibody [NB100-56500]

Western Blot: FNTA Antibody [NB100-56500]

Western Blot: FNTA Antibody [NB100-56500] - analysis of FNTA in mouse colon cell lysate in the 1) absence and 2) presence of immunizing peptide using FNTA antibody at 2 ug/ml.
Immunohistochemistry-Paraffin: FNTA Antibody [NB100-56500]

Immunohistochemistry-Paraffin: FNTA Antibody [NB100-56500]

Immunohistochemistry-Paraffin: FNTA Antibody [NB100-56500] - analysis of human prostate using FNTA antibody at 10 ug/ml.

Applications for FNTA Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 ug/ml

Western Blot

1-3 ug/ml

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FNTA

Principal Names: Farnesyltransferase, CAAX box (FNTA); alphaCAAX farnesyltransferase alpha subunit, FPTA, FTase-alpha, GGTase-I-alpha, Protein farnesyl transferase/ geranyl geranyl transferase type I alpha subunit(PGGT1A), Ras proteins prenyl transferase alpha, Type I protein geranyl-geranyl transferase alpha subunit; Official Gene Symbol: FNTA Gen Bank Accession Number: NP_002018, Gene ID: 2339 (human) Gene Map Locus: 8p11 (human) Prenylation is a common intracellular posttranslational protein modification catalyzed by prenyltransferases. The best characterized among these prenyltransferases is the CAAX farnesyl transferase (2.5.1.21), which is alpha-beta heterodimeric enzyme. It catalyzes the attachment of a farnesyl group from farnesyl phosphate to cysteine residues at the fourth position from the C terminus of proteins that end in the CAAX box. FNTA or the alpha subunit of farnesyl transferase is shared by the geranyl-geranyl protein transferases. Apart from transfer of farnesyl and geranyl groups to proteins, FNTA has been proposed to regulate intracellular signaling pathways involving p21ras. Reports have shown that FNTA interacts with TGF-beta and activin-type I receptors.

Long Name

Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha

Alternate Names

EC 2.5.1.58, EC 2.5.1.59, FTase-alpha, GGTase-I-alpha

Entrez Gene IDs

2339 (Human); 25318 (Rat)

Gene Symbol

FNTA

UniProt

P49354 (Human)

Additional FNTA Products

Product Documents for FNTA Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for FNTA Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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