FOLR2 Antibody (CL10) - Azide and BSA Free
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-81079
Recombinant Monoclonal Antibody
![Western Blot: FOLR2 Antibody (CL10)Azide and BSA Free [NBP2-81079]](https://resources.bio-techne.com/images/products/FOLR2-Antibody-CL10-Western-Blot-NBP2-81079-img0001.jpg "Western Blot: FOLR2 Antibody (CL10)Azide and BSA Free [NBP2-81079]")
Conjugate
Catalog #
Key Product Details
Species Reactivity
Mouse
Applications
Immunohistochemistry, Western Blot
Label
Unconjugated
Antibody Source
Recombinant Monoclonal Rat IgG2a Kappa Clone # CL10
Format
Azide and BSA Free
Concentration
1 mg/ml
Product Specifications
Immunogen
FRbeta -transfected RBL2H3 cells.
Clonality
Monoclonal
Host
Rat
Isotype
IgG2a Kappa
Scientific Data Images for FOLR2 Antibody (CL10) - Azide and BSA Free
Western Blot: FOLR2 Antibody (CL10)Azide and BSA Free [NBP2-81079]
Western Blot: FOLR2 Antibody (CL10) [NBP2-81079] - Mouse heart (lane 1), mouse lung (lane 2), mouse pancreas (lane 3), mouse testis (lane 4) and rat ovary (lane 5) samples were resolved on a 12% SDS PAGE gel and blots probed with NBP2-81079 at 1.5 ug/ml before being detected by a secondary antibody. Bands corresponding to the expected 29 kDa folate receptor protein as well as dimers thereof were detected.Applications for FOLR2 Antibody (CL10) - Azide and BSA Free
Application
Recommended Usage
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Western Blot
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
The antibody binds specifically to FRbeta, a member of the folate receptor family. The receptor binds with high affinity to folic acid and folic acid derivatives, and transports 5-methyltetrahydrofolate into the cell. The receptor is expressed on the surface of tumour associated macrophages (TAMs) that promote growth and metastasis of tumours such as gliomas and colon, breast and lung carcinomas. Research has shown FRbeta is only expressed on activated macrophages, and thereby a monoclonal antibody that targets the receptor can be useful in the diagnosis of the cancer. Furthermore, the antibody may be conjugated with a toxin, delivering the drug only to TAMs and not to healthy macrophages.
Formulation, Preparation, and Storage
Purification
Protein A purified
Formulation
PBS
Format
Azide and BSA Free
Preservative
0.02% Proclin 300
Concentration
1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C for up to 3 months. For longer storage, aliquot and store at -20C.
Background: FOLR2
Long Name
Folate Receptor 2
Alternate Names
beta-HFR, FR-beta, FR-P3
Gene Symbol
FOLR2
Additional FOLR2 Products
Product Documents for FOLR2 Antibody (CL10) - Azide and BSA Free
Product Specific Notices for FOLR2 Antibody (CL10) - Azide and BSA Free
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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