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FoxP2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-86671

Novus Biologicals, part of Bio-Techne
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NBP1-86671
NBP1-86671-25ul

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse, Rat

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: AQQLVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQLWKEVTGVHSMEDNGIKHGGLDLTTNNSSSTTSSNTSKASPPITHHS

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 25926446). Mouse reactivity reported in scientific literature (PMID: 26407299).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for FoxP2 Antibody

Western Blot: FoxP2 Antibody [NBP1-86671]

Western Blot: FoxP2 Antibody [NBP1-86671]

Western Blot: FoxP2 Antibody [NBP1-86671] - Analysis in human cell line RH-30.
Immunohistochemistry: FoxP2 Antibody [NBP1-86671]

Immunohistochemistry: FoxP2 Antibody [NBP1-86671]

Immunohistochemistry: FoxP2 Antibody [NBP1-86671] - Patterns of neocortical layer markers in the OT. Both CTIP2 and FOXP2 cells were broadly present in Layer 2 and scattered in Layer 3. Dorsal to top, lateral to right. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/26407299/) licensed under a CC-BY license.
Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671]

Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671]

Immunohistochemistry-Paraffin: FoxP2 Antibody [NBP1-86671] - Staining of human cerebral cortex shows moderate to strong nuclear positivity in neurons.

Applications for FoxP2 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

Reported in scientific literature (PMID: 25926446 and 25926446).

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200-1:500

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: FoxP2

FOXP2 encodes an evolutionarily conserved transcription factor expressed in fetal and adult brain. This transcription factor is a member of the forkhead/winged-helix (FOX) family of transcription factors, and contains a FOX DNA-binding domain and a large polyglutamine tract. Members of the FOX family of transcription factors are regulators of embryogenesis. The product of this gene is thought to be required for proper development of speech and language regions of the brain during embryogenesis. Although a point mutation in this gene has been associated with the KE pedigree segregating developmental verbal dyspraxia, no association between mutations in this gene and another speech disorder, autism, has been found. Four alternative transcripts encoding three different isoforms have been identified.

Long Name

Forkhead Box P2

Alternate Names

CAGH44, SPCH1, TNRC10

Gene Symbol

FOXP2

Additional FoxP2 Products

Product Documents for FoxP2 Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for FoxP2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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