FoxP3 Antibody (FOXP3/7990R) [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-20941F

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Product Datasheet / COA / SDS

Recombinant Monoclonal Antibody

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP3-20675

Alexa Fluor 350

NBP3-20941AF350

Alexa Fluor 405

NBP3-20941AF405

Alexa Fluor 488

NBP3-20941AF488

Alexa Fluor 532

NBP3-20941AF532

Alexa Fluor 594

NBP3-20941AF594

Alexa Fluor 647

NBP3-20941AF647

Alexa Fluor 700

NBP3-20941AF700

Alexa Fluor 750

NBP3-20941AF750

Allophycocyanin

NBP3-20941APC

Biotin

NBP3-20941B

CoraFluor 1

NBP3-20941CL1

DyLight 350

NBP3-20941UV

DyLight 405

NBP3-20941V

DyLight 488

NBP3-20941G

DyLight 550

NBP3-20941R

DyLight 594

NBP3-20941DL594

DyLight 650

NBP3-20941C

DyLight 680

NBP3-20941FR

DyLight 755

NBP3-20941IR

HRP

NBP3-20941H

Janelia Fluor 525

NBP3-20941JF525

Janelia Fluor 549

NBP3-20941JF549

Janelia Fluor 585

NBP3-20941JF585

Janelia Fluor 635

NBP3-20941JF635

Janelia Fluor 646

NBP3-20941JF646

Janelia Fluor 669

NBP3-20941JF669

PE

NBP3-20941PE

PerCP

NBP3-20941PCP

Forumulation

Catalog #

Azide and BSA Free

NBP3-20941

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

FITC (Excitation = 495 nm, Emission = 519 nm)

Antibody Source

Recombinant Monoclonal Rabbit IgG Kappa Clone # FOXP3/7990R

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all FoxP3 Antibodies »

Product Summary for FoxP3 Antibody (FOXP3/7990R) [FITC]

Immunogen

Recombinant fragment (around aa300-431) of human FoxP3 protein (exact sequence is proprietary)

Localization

Nucleus. Cytoplasm.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG Kappa

Applications for FoxP3 Antibody (FOXP3/7990R) [FITC]

Application

Recommended Usage

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: FoxP3

Forkhead box P3 (FoxP3), aka Scurfin and JM2, is a protein involving in immune system responses and functioning as a transcriptional regulator crucial in the development and inhibitory of regulatory T-Cells (Treg). FoxP3 is a master regulator of the Treg lineage, who requires Ahr and STAT-5 and other additional transcription factors to retains its complete function and differentiation. Scurfin remains steady and constitutively expressed in two conditions: a high level in CD25 + CD4 positive regulatory T cells and a low level in CD4 positive/CD25 negative cells. JM2 is absent in CD4 negative/CD8 positive T cells. FoxP3 defects are related to various cancers and autoimmune diseases, and X-linked syndrome (IPEX), while overexpression may also cause severe immunodeficiency.

Long Name

Forkhead Box P3

Alternate Names

AIID, DIETER, IPEX, JM2, PIDX, SCURFIN, XPID

Gene Symbol

FOXP3

Additional FoxP3 Products

Product Documents for FoxP3 Antibody (FOXP3/7990R) [FITC]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for FoxP3 Antibody (FOXP3/7990R) [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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