G2A/GPR132 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-69090

Novus Biologicals, part of Bio-Techne
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NBP2-69090
NBP2-69090-0.025ml
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Key Product Details

Species Reactivity

Human, Mouse, Monkey

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all G2A/GPR132 Antibodies »

Product Specifications

Immunogen

Synthesized peptide derived from the C-terminal region of human G2A/GPR132.

Specificity

Detects endogenous levels of G2A/GPR132 protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for G2A/GPR132 Antibody

Western Blot: G2A/GPR132 Antibody [NBP2-69090]

Western Blot: G2A/GPR132 Antibody [NBP2-69090]

Western Blot: G2A/GPR132 Antibody [NBP2-69090] - Analysis of 293T cells.

Applications for G2A/GPR132 Antibody

Application
Recommended Usage

ELISA

1:5000

Immunocytochemistry/ Immunofluorescence

1:200-1:1000

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS, 50% glycerol, 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: G2A/GPR132

GPR132, also known as G2A (for G2 accumulation), is a seven transmembrane G protein-coupled receptor that is upregulated in response to DNA damage and stress. G2A is predominantly expressed in hematopoietic tissues and in hematopoietic stem cells, and it is more highly detected in pro-B cells, while lower expression is observed in immature B cells and pre-B cells. G2A is expressed throughout T cell maturation, and it is further increased in response to T-cell activation. Ectopic expression of a G2A fusion protein in NIH/3T3 fibroblasts induces a cell cycle arrest that is consistent with a block at the G2/M transition. G2A is also able to attenuate the proliferative effects of Bcr-Abl, a chimeric tyrosine kinase oncogene, suggesting that G2A possesses anti-oncogenic properties. The amino acid sequence of G2A contains a destruction box motif that is consistently observed in cyclins, where it is required for ubiquitination and proteolytic degradation.

Long Name

G2 Accumulation Protein

Alternate Names

GPR132

Gene Symbol

GPR132

Additional G2A/GPR132 Products

Product Documents for G2A/GPR132 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for G2A/GPR132 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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