GAB2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-61653

Novus Biologicals, part of Bio-Techne
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NB100-61653
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GAB2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QVDKEKTQALQN corresponding to internal region (near C-Terminus) according to NP_036428.1.

Epitope

QVDKEKTQALQN

Specificity

This antibody is expected to recognize both reported isoforms (NP_536739.1; NP_036428.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GAB2 Antibody

Western Blot: GAB2 Antibody [NB100-61653]

Western Blot: GAB2 Antibody [NB100-61653]

Western Blot: GAB2 Antibody [NB100-61653] - (0.5ug/ml) staining of K562 cell lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for GAB2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:64000

Western Blot

0.5 - 1.5 ug/ml
Application Notes
WB: Approx. 80 kDa band observed in K562 lysates (calculated MW of 74.5 kDa band according to NP_536739.1).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GAB2

This gene is a member of the GRB2-associated binding protein (GAB) gene family and is similar to the GAB1 gene. These proteins contain pleckstrin homology (PH) domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. They act as adapters for transmitting various signals in response to stimuli through cytokine and growth factor receptors, and T- and B-cell antigen receptors. The protein encoded by this gene is the principal activator of phosphatidylinositol-3 kinase in response to activation of the high affinity IgE receptor. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.

Long Name

GRB2-associated Binding Protein 2

Alternate Names

p100

Entrez Gene IDs

9846 (Human); 14389 (Mouse); 84477 (Rat)

Gene Symbol

GAB2

UniProt

NP_536739.1 (Human)

Additional GAB2 Products

Product Documents for GAB2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GAB2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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