GABA-AR alpha 6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-26069

Novus Biologicals, part of Bio-Techne
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NBP2-26069
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Key Product Details

Species Reactivity

Human, Bovine

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GABA-A R alpha 6 Antibodies »

Product Specifications

Immunogen

Peptide with sequence ENALGKLEVEGN-C corresponding to N-Terminus according to NP_000802.2.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GABA-AR alpha 6 Antibody

Immunohistochemistry-Paraffin: GABA-AR alpha 6 Antibody [NBP2-26069]

Immunohistochemistry-Paraffin: GABA-AR alpha 6 Antibody [NBP2-26069]

Immunohistochemistry-Paraffin: GABA-A R alpha 6 Antibody [NBP2-26069] - Staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for GABA-AR alpha 6 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Peptide ELISA

Detection limit 1:128000

Western Blot

1:100 - 1:2000
Application Notes
WB: Preliminary experiments gave bands at approx. 75 kDa band and 37 kDa band in human cerebellum lysates after 0.3 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 51.0 kDa band according to NP_000802.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GABA-A R alpha 6

GABA (A) receptors are ligand-gated chloride channels that play a role as inhibitory neurotransmitters. They are known targets for certain classes of environmental and pharmaceutical compounds because a number of drugs interact with binding sites on GABA (A). Some of these drugs include benzodiazepines, anticonvulsants, and anesthetics. GABA (A) Receptors are comprised of subunits and these are further classified into 3 major groups (alpha, beta, and gamma). The subunits determine the pharmacological characteristics. The alpha 6 subunit is expressed in cerebellar granule cells. Though it is concentrated at synapses, it is found on extrasynaptic membranes, as well.

Long Name

gamma-Aminobutyric Acid Type A Receptor, alpha-6 Polypeptide

Alternate Names

GABAAR alpha 6, GABAARa6, GABRA6

Entrez Gene IDs

2559 (Human)

Gene Symbol

GABRA6

Additional GABA-A R alpha 6 Products

Product Documents for GABA-AR alpha 6 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-AR alpha 6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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