GABA-B R1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS5332

Novus Biologicals, part of Bio-Techne
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NLS5332
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Porcine, Bat, Bovine, Canine, Equine, Hamster, Monkey, Primate

Predicted:

Orangutan (100%), Rabbit (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all GABA-B R1 Antibodies »

Product Specifications

Immunogen

Synthetic 15 amino acid peptide from N-terminal extracellular domain of human GABA-B R1.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Xenopus (87%), Zebrafish (87%), Opossum (80%).

Localization

Cell Membrane

Specificity

Human GABBR1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for GABA-B R1 Antibody - BSA Free

Immunohistochemistry-Paraffin: GABA-B R1 Antibody - BSA Free [NLS5332]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody - BSA Free [NLS5332]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody [NLS5332] - Anti-GABABR1 / GABBR1 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Immunohistochemistry-Paraffin: GABA-B R1 Antibody - BSA Free [NLS5332]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody - BSA Free [NLS5332]

Immunohistochemistry-Paraffin: GABA-B R1 Antibody [NLS5332] - GABA B Receptor 1 Antibody [NLS5332] - IHC analysis of Brain, Neurons and glia using NLS5332 at 7 ug/ ml.

Applications for GABA-B R1 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

7 - 13 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: GABA-B R1

GABA(B) receptor 1, a GABA(B) Receptor, forms a heterodimer with GABA(B) receptor 2 to mediate the effects of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system. Activation of this receptor leads to fast synaptic inhibition. Reduced GABA(B) receptor 1a-b expression is implicated in the pathophysiology of temporal-lobe epilepsy. In primates, GABA(B) receptors are widely distributed and are located to subserve both pre- and postsynaptic roles in controlling synaptic transmission in the primate basal ganglia. Five alternatively spliced protein isoforms of GABA(B) receptor 1 have been identified. GABA(B) receptor 1 is widely expressed, with highest levels reported in brain, and lower levels in gastrointestinal tract, kidney, and uterus. ESTs have been isolated from a wide variety of tissues, including adrenal, brain, breast, colon, embryo, eye, ganglion, head/neck, heart, heart/melanocyte/uterus, liver/spleen, lung, nerve, placenta, prostate, stomach, testis, and tonsil libraries, among others.

Long Name

gamma-Aminobutyric Acid Type B Receptor Subunit 1

Alternate Names

GABABR1, GABBR1, Gb1, GPRC3A

Entrez Gene IDs

2550 (Human)

Gene Symbol

GABBR1

Additional GABA-B R1 Products

Product Documents for GABA-B R1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for GABA-B R1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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