GABA-B R2 Antibody (5G7B9) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-37280

Novus Biologicals, part of Bio-Techne
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NBP2-37280
NBP2-37280-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # 5G7B9

Format

BSA Free

Concentration

1 mg/ml

View all GABA-B R2 Antibodies »

Product Summary for GABA-B R2 Antibody (5G7B9) - BSA Free

Immunogen

Purified recombinant fragment of human GABA-B R2 (AA: 319-483) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Theoretical MW

105.8 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GABA-B R2 Antibody (5G7B9) - BSA Free

Western Blot: GABA-B R2 Antibody (5G7B9)BSA Free [NBP2-37280]

Western Blot: GABA-B R2 Antibody (5G7B9)BSA Free [NBP2-37280]

Western Blot: GABA-B R2 Antibody (5G7B9) [NBP2-37280] - Analysis using GABBR2 mAb against HEK293 (1) and GABBR2 (AA: 319-483)-hIgGFc transfected HEK293 (2) cell lysate.
Immunohistochemistry-Paraffin: GABA-B R2 Antibody (5G7B9) - BSA Free [NBP2-37280]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody (5G7B9) - BSA Free [NBP2-37280]

Immunohistochemistry-Paraffin: GABA-B R2 Antibody (5G7B9) [NBP2-37280] - Analysis of cerebellum tissues using GABBR2 mouse mAb with DAB staining.
Western Blot: GABA-B R2 Antibody (5G7B9)BSA Free [NBP2-37280]

Western Blot: GABA-B R2 Antibody (5G7B9)BSA Free [NBP2-37280]

Western Blot: GABA-B R2 Antibody (5G7B9) [NBP2-37280] - Analysis using GABBR2 mAb against human GABBR2 (AA: 319-483) recombinant protein. (Expected MW is 44.9 kDa)
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Applications for GABA-B R2 Antibody (5G7B9) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Immunohistochemistry

1:200 - 1:1000

Immunohistochemistry-Paraffin

1:200 - 1:1000

Western Blot

1:500 - 1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GABA-B R2

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors the GABAA and the GABAB subtype of receptors. GABAB receptors are heterodimeric G protein-coupled receptors that mediate slow synaptic inhibition in the central nervous system. Moss and colleagues (Couve, et al., 2002) recently demonstrated that the functional coupling of GABAB R1/GABAB R2 receptors to inwardly rectifying K+ channels rapidly desensitizes. This effect is alleviated after direct phosphorylation of a single serine residue (Ser892) in the cytoplasmic tail of GABAB R2 by cyclic AMP (cAMP)-dependent protein kinase (PKA). In addition to it postsynaptic effects GABAB receptors localized to the presynaptic region have been reported to restrict the availability of synaptic vesicles for release (Sakaba and Neher, 2003).

Long Name

gamma-Aminobutyric Acid Type B Receptor Subunit 2

Alternate Names

GABABR2, GABBR2, GPR51, GPRC3B

Gene Symbol

GABBR2

Additional GABA-B R2 Products

Product Documents for GABA-B R2 Antibody (5G7B9) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GABA-B R2 Antibody (5G7B9) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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