GEMIN2 Antibody (OTI4C11)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-45831

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # OTI4C11

Concentration

1 mg/ml

View all GEMIN2 Antibodies »

Product Specifications

Immunogen

Full length human recombinant protein of human GEMIN2(NP_003607) produced in E.coli.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

31.4 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GEMIN2 Antibody (OTI4C11)

Western Blot: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Western Blot: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Western Blot: SIP1 Antibody (4C11) [NBP2-45831] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY GEMIN2 .
Immunohistochemistry: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Immunohistochemistry: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Immunohistochemistry: GEMIN2 Antibody (4C11) [NBP2-45831] - SIP1 Antibody (4C11) [NBP2-45831] - Analysis of Human tonsil tissue.(Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)(1:150)
Immunohistochemistry: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Immunohistochemistry: GEMIN2 Antibody (OTI4C11) [NBP2-45831]

Immunohistochemistry: GEMIN2 Antibody (4C11) [NBP2-45831] - SIP1 Antibody (4C11) [NBP2-45831] - Analysis of Human lymph node tissue. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120C for 3 min)(1:150)
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Applications for GEMIN2 Antibody (OTI4C11)

Application
Recommended Usage

Immunohistochemistry

1:150

Western Blot

1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.3), 1.0% BSA and 50% Glycerol

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GEMIN2

SIP1 encodes one of the proteins found in the SMN complex, which consists of the suvival of motor neuron protein and several gemin proteins. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration.

Alternate Names

Component of gems 2, gemin-2, GEMIN2survival of motor neuron protein-interacting protein 1, SIP1-delta, SMN interacting protein 1-delta, SMN-interacting protein 1, survival of motor neuron protein interacting protein 1

Gene Symbol

GEMIN2

Additional GEMIN2 Products

Product Documents for GEMIN2 Antibody (OTI4C11)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GEMIN2 Antibody (OTI4C11)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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