Gephyrin/GPHN Antibody (9D0B0)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-16472

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-16472-100ul
NBP3-16472-20ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 9D0B0

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Gephyrin/GPHN Antibodies »

Product Summary for Gephyrin/GPHN Antibody (9D0B0)

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Gephyrin/GPHN (NP_001019389). MATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKETLIDWCDEKELNLILTTGGTGFAPRDVTPEAT

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Gephyrin/GPHN Antibody (9D0B0)

Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472]

Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472]

Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472] - Western blot analysis of extracts of various cell lines, using Gephyrin/GPHN Rabbit mAb (NBP3-16472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.
Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472]

Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472]

Western Blot: Gephyrin/GPHN Antibody (9D0B0) [NBP3-16472] - Western blot analysis of extracts of various cell lines, using Gephyrin/GPHN Rabbit mAb (NBP3-16472) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 3min.

Applications for Gephyrin/GPHN Antibody (9D0B0)

Application
Recommended Usage

Western Blot

1:500 - 1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Gephyrin/GPHN

The Gephyrin (GPHN) gene encodes a neuronal assembly protein that exists in isoform 1 (736 amino acids long, 79 kDA) or isoform 2 (769 amino acids in length, approximately 83 kDA). This protein anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton through high affinity binding to a receptor subunit domain and tublin dimers. The protein coded by GPHN is also necessary for molybdenum biosynthesis. The GPHN gene has been investigated in relation to many diseases such as leukemia, cervicitis, tuberculosis, alzheimer's disease, anorexia nervosa, huntington's disease, retinitis, and herpes zoster. The GPHN gene interacts with genes DYNLL1, PFN1, PRPF4, ENAH, and SLX4 to participate in pathways that regulate metabolism of vitamins and cofactors as well as molybdenum cofactor biosynthesis.

Alternate Names

GEPH, GPH, GPHN, GPHRYN

Gene Symbol

GPHN

Additional Gephyrin/GPHN Products

Product Documents for Gephyrin/GPHN Antibody (9D0B0)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Gephyrin/GPHN Antibody (9D0B0)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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