GFR alpha-2/GDNF R alpha-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89778

Novus Biologicals, part of Bio-Techne
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NBP1-89778
NBP1-89778-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Mouse (96%), Rat (97%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all GFR alpha-2/GDNF R alpha-2 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for GFR alpha-2/GDNF R alpha-2 Antibody

Western Blot: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778]

Western Blot: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778]

Western Blot: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778] - Analysis in human thyroid gland tissue.
Immunohistochemistry-Paraffin: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778]

Immunohistochemistry-Paraffin: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778]

Immunohistochemistry-Paraffin: GFR alpha-2/GDNF R alpha-2 Antibody [NBP1-89778] - Staining of human lymph node shows strong cytoplasmic positivity in reaction center cells and lymphoid cells outside reaction centra.

Applications for GFR alpha-2/GDNF R alpha-2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GFR alpha-2/GDNF R alpha-2

Members of the glial cell line derived neurotrophic factor (GDNF) family, including GDNF and neurturin (NTN), play key roles in the control of vertebrate neuron survival and differentiation. Physiological responses to NTN require the presence of a novel glycosylphosphadidylinositol linked protein NTNRa, which is a cell surface receptor for NTN. The cDNAs encoding NTNRa from human, rat, chicken, and mouse have been cloned recently. NTNRa was also termed GDNFRb, Ret ligand 2 (RETL2) or TGFb related neurotrophic factor receptor 2 (TrnR2) and nominated as GFRa2 recently. GFRa2 binds NTN and mediates activation of RET receptor tyrosine kinase by both NTN and GDNF. Thus, NTN, GFRa2, and the Ret PTK form a complex to transduce NTN signal and to mediate NTN function.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 2

Alternate Names

GDNF R alpha-2, GFR alpha2, GFRa-2, GFRA2

Gene Symbol

GFRA2

Additional GFR alpha-2/GDNF R alpha-2 Products

Product Documents for GFR alpha-2/GDNF R alpha-2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GFR alpha-2/GDNF R alpha-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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