Glial cell line-derived neurotrophic factor (GDNF) and the related neurotrophic factor neurturin (NTN) are potent survival factors for central and peripheral neurons. Receptors for these factors include GFRalpha-1 (previously designated GDNFR-alpha), GFRalpha-2 (also designated RETL2), GFRalpha-3 and GFRalpha-4 (also known as persephin receptor). The receptors do not contain transmembrane domains and are attached to the cell membrane by glycosylphosphoinositol linkage. Binding of GDNF or NTN to one of these receptors leads to the activation of the tyrosine kinase Ret. GFRalpha-4 mediates the activation and GDNF-induced autophosphorylation of the RET receptor. It is mainly expressed in the adult thyroid gland, but lower levels may also be detected in fetal adrenal and thyroid glands.

Long Name

Glial Cell line-derived Neurotrophic Factor Receptor alpha 4

Alternate Names

GDNF R alpha-4, GFR alpha4, GFRa-4, GFRA4

Gene Symbol

GFRA4

UniProt

NP_071422

Additional GFR alpha-4/GDNF R alpha-4 Products

Product Documents

Product Datasheets

Download Product Datasheets

COA

SDS

Download SDS

Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Citations
Reviews

GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34) - Azide and BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-12414

Key Product Details

Species Reactivity

Applications

Label

Antibody Source

Format

Concentration

View all GFR alpha-4/GDNF R alpha-4 Antibodies »

Product Specifications

Immunogen

Clonality

Host

Isotype

Scientific Data Images

Western Blot: GFR alpha-4/GDNF R alpha-4/Persephin receptor Antibody (MM0311-3P34)Azide and BSA Free [NBP2-12414]

Applications

Western Blot

Formulation, Preparation, and Storage

Purification

Reconstitution

Formulation

Format

Preservative

Concentration

Shipping

Stability & Storage

Background: GFR alpha-4/GDNF R alpha-4