GGCX Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-51964

Novus Biologicals, part of Bio-Techne
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NBP1-51964
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all GGCX Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-PPESNPDPVHSE corresponding to C-Terminus according to NP_000812.2, NP_001135741.1.

Epitope

C-PPESNPDPVHSE

Specificity

This antibody is expected to recognize both isoforms (NP_000812.2; NP_001135741.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for GGCX Antibody

Western Blot: GGCX Antibody [NBP1-51964]

Western Blot: GGCX Antibody [NBP1-51964]

Western Blot: GGCX Antibody [NBP1-51964] - Analysis of GGCX in Human Muscle lysate (35ug protein in RIPA buffer) using NBP1-51964 at 0.3 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.
Immunohistochemistry-Paraffin: GGCX Antibody [NBP1-51964]

Immunohistochemistry-Paraffin: GGCX Antibody [NBP1-51964]

Immunohistochemistry-Paraffin: GGCX Antibody [NBP1-51964] - Staining of paraffin embedded Human Kidney. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Applications for GGCX Antibody

Application
Recommended Usage

Immunohistochemistry

5 - 10 ug/ml

Immunohistochemistry-Paraffin

5 - 10 ug/ml

Peptide ELISA

Detection limit 1:32000

Western Blot

0.3 - 1 ug/ml
Application Notes
WB: Approx. 85 kDa band observed in human muscle lysates (calculated MW of 85 kDa band according to NP_000812.2). IHC-P: Human kidney shows distinct staining in the cytoplasm of epthelial cells.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GGCX

Gamma-glutamyl carboxylase (GGCX) mediates the vitamin K-dependent carboxylation of glutamate residues to calcium binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide. GGCX accomplishes the posttranslational modification required for the activity of all of the vitamin K-dependent proteins. These include some of the blood coagulation and anticoagulation proteins as well as bone gamma-carboxyglutamic acid (Gla) protein (BGLAP) and bone matrix protein (MGP)

Long Name

Gamma-Glutamyl Carboxylase

Alternate Names

VKCFD1

Entrez Gene IDs

2677 (Human)

Gene Symbol

GGCX

UniProt

NP_000812.2 (Human)

Additional GGCX Products

Product Documents for GGCX Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GGCX Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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