GLP-1R Antibody [Janelia Fluor® 646]

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-97308JF646

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Alexa Fluor 350

NBP1-97308AF350

Alexa Fluor 405

NBP1-97308AF405

Alexa Fluor 488

NBP1-97308AF488

Alexa Fluor 532

NBP1-97308AF532

Alexa Fluor 594

NBP1-97308AF594

Alexa Fluor 647

NBP1-97308AF647

Alexa Fluor 700

NBP1-97308AF700

Alexa Fluor 750

NBP1-97308AF750

Allophycocyanin

NBP1-97308APC

Biotin

NBP1-97308B

CoraFluor 1

NBP1-97308CL1

DyLight 350

NBP1-97308UV

DyLight 405

NBP1-97308V

DyLight 488

NBP1-97308G

DyLight 550

NBP1-97308R

DyLight 594

NBP1-97308DL594

DyLight 650

NBP1-97308C

DyLight 680

NBP1-97308FR

DyLight 755

NBP1-97308IR

FITC

NBP1-97308F

HRP

NBP1-97308H

Janelia Fluor 525

NBP1-97308JF525

Janelia Fluor 549

NBP1-97308JF549

Janelia Fluor 585

NBP1-97308JF585

Janelia Fluor 635

NBP1-97308JF635

Janelia Fluor 669

NBP1-97308JF669

mFluor Violet 450 SE

NBP1-97308MFV450

mFluor Violet 500 SE

NBP1-97308MFV500

mFluor Violet 610 SE

NBP1-97308MFV610

PE

NBP1-97308PE

PerCP

NBP1-97308PCP

Forumulation

Catalog #

BSA Free

NBP1-97308

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Canine

Applications

Dot Blot, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Knockdown Validated, Simple Western, Western Blot

Label

Janelia Fluor 646

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GLP-1R Antibodies »

Product Summary for GLP-1R Antibody [Janelia Fluor® 646]

Immunogen

A synthetic peptide made to an internal portion of the human GLP1R protein (between residues 250-350) [UniProt P43220]

Reactivity Notes

Rat reactivity reported in scientific literature (PMID: 27435156). Canine reactivity reported in scientific literature (PMID: 25747753).

Localization

Cell membrane; Multi-pass membrane protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for GLP-1R Antibody [Janelia Fluor® 646]

Application

Recommended Usage

Dot Blot

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Knockdown Validated

Optimal dilutions of this antibody should be experimentally determined.

Simple Western

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

50mM Sodium Borate

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: GLP-1R

GLP1R, a Glucagon Receptor, has been suggested to affect the feelings of satiety or hunger, sensation of glucose levels, control of glucagon sensitivity of islets, and non insulin-dependent diabetes mellitus. Glucagon-like peptide 1 is an incretin hormone produced by enteroendocrine L-cells in the intestinal mucosa. The hormone is released in response to food intake and plays an important role in maintaining blood glucose homeostasis. Stimulation of the GLP-1R by endogenous hormone induces multiple complementary mechanisms, which together result in a lowering of circulating blood glucose levels. These mechanisms include receptor-mediated enhancement of glucose-induced insulin secretion from pancreatic -cells, inhibition of gastric emptying with a delay in the gastrointestinal resorption of nutrients, inhibition of glucagon secretion, and inhibition of food intake. Desensitization of GLP1R on pancreatic beta-cells is one of the causes of non insulin-dependent diabetes mellitus (NIDDM). GLP1R knockout mice are viable, develop normally, but exhibit increased levels of blood glucose following oral glucose challenge in association with diminished levels of circulating insulin. Recently it has been shown that overexpression of glucagon-like peptide-1 receptor improves learning in rats (During et al. 2003). GLP1R has been reported in pancreas, brain, heart, kidney, lung, and stomach. ESTs have been isolated from kidney and skin libraries.

Long Name

Glucagon-like Peptide 1 Receptor

Alternate Names

GLP1R

Gene Symbol

GLP1R

Additional GLP-1R Products

Product Documents for GLP-1R Antibody [Janelia Fluor® 646]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for GLP-1R Antibody [Janelia Fluor® 646]

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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