Glucuronosyltransferase 1A1/UGT1A1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-69448

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all Glucuronosyltransferase 1A1/UGT1A1 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to UGT1A1(UDP glucuronosyltransferase 1 family, polypeptide A1) The peptide sequence was selected from the middle region of UGT1A1 (NP_000454). Peptide sequence ASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEH. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for Glucuronosyltransferase 1A1/UGT1A1 Antibody

Western Blot: Glucuronosyltransferase 1A1/UGT1A1 Antibody [NBP1-69448]

Western Blot: Glucuronosyltransferase 1A1/UGT1A1 Antibody [NBP1-69448]

Western Blot: UGT1A1 Antibody [NBP1-69448] - This Anti-UGT1A1 antibody was used in Western Blot of Fetal Liver tissue lysate at a concentration of 2.5ug/ml.

Applications for Glucuronosyltransferase 1A1/UGT1A1 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Glucuronosyltransferase 1A1/UGT1A1

UGT1A1 is a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids.This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The preferred substrate of this enzyme is bilirubin, although it also has moderate activity with simple phenols, flavones, and C18 steroids. Mutations in this gene result in Crigler-Najjar syndromes types I and II and in Gilbert syndrome.

Long Name

UDP Glucuronosyltransferase 1A1

Alternate Names

GNT1, UDPGT 1-1, UG-BR1, UGT1, UGT1A

Entrez Gene IDs

54658 (Human)

Gene Symbol

UGT1A1

UniProt

P22309 (Human)

Additional Glucuronosyltransferase 1A1/UGT1A1 Products

Product Documents for Glucuronosyltransferase 1A1/UGT1A1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Glucuronosyltransferase 1A1/UGT1A1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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