GluR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB300-301

Novus Biologicals, part of Bio-Techne
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NB300-301
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Key Product Details

Species Reactivity

Validated:

Rat

Predicted:

Chicken (100%), Human (100%), Mouse (100%), Primate (100%), Zebrafish (100%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GluR2 Antibodies »

Product Summary for GluR2 Antibody

Immunogen

Synthetic peptide corresponding to amino acid residues specific to GluR2 conjugated to KLH. Accession # P19491

Reactivity Notes

Tested in Rat. It is anticipated that the antibody will also react with chicken, human, mouse, non-human primates and zebra fish based on the fact that these species have 100% homology with the amino acid sequence used as antigen.

Localization

Cell Membrane

Specificity

Specific for endogenous levels of the ~100 kDa GluR2 protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

100 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GluR2 Antibody

Western Blot: GluR2 Antibody [NB300-301]

Western Blot: GluR2 Antibody [NB300-301]

Western Blot: Glutamate Receptor 2 Antibody [NB300-301] - Rat hippocampal lysate showing the specific immunolabeling or the ~100k GluR 2 protein using NB300-301.

Applications for GluR2 Antibody

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: GluR2

The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D- aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct Glutamate Receptor Subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain. The GluR2 subunit is thought to play a key role in forms of synaptic plasticity such as LTD.

Long Name

Glutamate Receptor 2

Alternate Names

AMPA2, GluA2, GluR-K2, GLURB, GRIA2, HBGR2

Entrez Gene IDs

2891 (Human); 14799 (Mouse); 29627 (Rat)

Gene Symbol

GRIA2

UniProt

P19491 (Rat)

Additional GluR2 Products

Product Documents for GluR2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for GluR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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