GluR2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-46490

Novus Biologicals, part of Bio-Techne
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NBP1-46490-0.025ml
NBP1-46490
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Frozen, Immunoprecipitation, Western Blot

Cited:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry-Frozen, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all GluR2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide from extracellular domain of human GluR2 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Applications for GluR2 Antibody

Application
Recommended Usage

Immunohistochemistry

1:300-1:2000

Immunohistochemistry-Frozen

1:300-1:2000

Western Blot

1:300-1:2000
Application Notes
The optimal dilution should be determined by the end user. Use in immunoprecipitation reported in scientific literature (PMID: 27461448). Use in ICC/IF, and IHC-FR reported in scientific literature (PMID: 30150703).

Formulation, Preparation, and Storage

Purification

Unpurified

Reconstitution

Reconstitute in 0.1 ml of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability. Please note the sample size is provided in reconstituted format.

Formulation

Lyophilized from whole antisera

Preservative

No Preservative

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GluR2

L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The ionotropic glutamate receptors are multimeric assemblies of four or five subunits, and are subdivided into three groups (AMPA, NMDA and Kainate receptors) based on their pharmacology structural similarities. The ionotropic receptors are ligand gated ion channels, i.e. on binding glutamate that has been released from a companion cell, charged ions such as Na+ and Ca2+ pass through a channel in the centre of the receptor complex. This flow of ions results in a depolarisation of the plasma membrane and the generation of an electrical current that is propagated down the processes (dendrites and axons) of the neuron to the next in line.

Long Name

Glutamate Receptor 2

Alternate Names

AMPA2, GluA2, GluR-K2, GLURB, GRIA2, HBGR2

Entrez Gene IDs

2891 (Human)

Gene Symbol

GRIA2

Additional GluR2 Products

Product Documents for GluR2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for GluR2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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