GNAQ Antibody (GNAQ/2434) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08585PE

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # GNAQ/2434

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GNAQ Antibodies »

Product Specifications

Immunogen

Recombinant full-length human GNAQ protein (Uniprot: P50148)

Localization

Cytoplasmic and Cell Surface

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Applications for GNAQ Antibody (GNAQ/2434) [PE]

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: GNAQ

GNAQ, also known as Guanine nucleotide-binding protein G(q) subunit alpha, is a 359 amino acid that is 42 kDa, with subcellular nucleus location, expressed in ovary, prostate, testis and colon tissue; necessary modulator or transducer in various transmembrane signaling systems; controls B-cell selection and survival, needed to prevent B-cell-dependent autoimmunity; and also regulates chemotaxis of BM-derived neutrophils and dendritic cells. Studies on this protein have shown a relationship with the following diseases and disorders: bleeding diathesis due to gnaq deficiency, cellular blue nevus, pertussis, melanoma, acanthocytosis, fainting, polycystic ovary syndrome, trypanosomiasis, gitelman syndrome chorea, thyroid nodule, huntington's disease, thyroiditis, chagas disease, alzheimer's disease, melanoma metastasis, vasculitis, neuronitis, erythroleukemia, and heart failure. GNAQ has also shown an interaction with AGTR1, CXCR5, CRHR1, GALR2, HTR2C, and over 100 other interacting proteins in many different pathways including calcium signaling pathway, vascular smooth muscle contraction, gap junction, long-term potentiation, glutamatergic synapse, GPCR downstream signaling, hemostasis, gastrin-CREB signalling pathway via PKC and MAPK, signaling by GPCR, signal amplification.

Alternate Names

GAQG-ALPHA-q, guanine nucleotide binding protein (G protein), q polypeptide, Guanine nucleotide-binding protein alpha-q, guanine nucleotide-binding protein G(q) subunit alpha

Gene Symbol

GNAQ

Additional GNAQ Products

Product Documents for GNAQ Antibody (GNAQ/2434) [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GNAQ Antibody (GNAQ/2434) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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