GNAQ Antibody (S05-5D7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15034

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15034-100ul
NBP3-15034-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S05-5D7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all GNAQ Antibodies »

Product Summary for GNAQ Antibody (S05-5D7)

Immunogen

A synthetic peptide of human GNAQ (Uniprot#: P50148)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

42 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GNAQ Antibody (S05-5D7)

Western Blot: GNAQ Antibody (S05-5D7) [NBP3-15034]

Western Blot: GNAQ Antibody (S05-5D7) [NBP3-15034]

Western Blot: GNAQ Antibody (S05-5D7) [NBP3-15034] - Western blot detection of GNAQ in Rat Brain, C6, 3T3 cell lysates using GNAQ Rabbit mAb (1:1000 diluted). Predicted band size: 42kDa. Observed band size: 42kDa.

Applications for GNAQ Antibody (S05-5D7)

Application
Recommended Usage

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GNAQ

GNAQ, also known as Guanine nucleotide-binding protein G(q) subunit alpha, is a 359 amino acid that is 42 kDa, with subcellular nucleus location, expressed in ovary, prostate, testis and colon tissue; necessary modulator or transducer in various transmembrane signaling systems; controls B-cell selection and survival, needed to prevent B-cell-dependent autoimmunity; and also regulates chemotaxis of BM-derived neutrophils and dendritic cells. Studies on this protein have shown a relationship with the following diseases and disorders: bleeding diathesis due to gnaq deficiency, cellular blue nevus, pertussis, melanoma, acanthocytosis, fainting, polycystic ovary syndrome, trypanosomiasis, gitelman syndrome chorea, thyroid nodule, huntington's disease, thyroiditis, chagas disease, alzheimer's disease, melanoma metastasis, vasculitis, neuronitis, erythroleukemia, and heart failure. GNAQ has also shown an interaction with AGTR1, CXCR5, CRHR1, GALR2, HTR2C, and over 100 other interacting proteins in many different pathways including calcium signaling pathway, vascular smooth muscle contraction, gap junction, long-term potentiation, glutamatergic synapse, GPCR downstream signaling, hemostasis, gastrin-CREB signalling pathway via PKC and MAPK, signaling by GPCR, signal amplification.

Alternate Names

GAQG-ALPHA-q, guanine nucleotide binding protein (G protein), q polypeptide, Guanine nucleotide-binding protein alpha-q, guanine nucleotide-binding protein G(q) subunit alpha

Gene Symbol

GNAQ

Additional GNAQ Products

Product Documents for GNAQ Antibody (S05-5D7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for GNAQ Antibody (S05-5D7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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