Granulin Antibody (CL5692)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61424

Novus Biologicals, part of Bio-Techne
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NBP2-61424
NBP2-61424-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL5692

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Granulin Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: SCPDGYTCCRLQSGAWGCCPFTQAVCCEDHIHCCPAGFTCDTQKGTCEQGPHQVPWMEKAPAHLSLPDPQALKRDVPCDNVSSCPSSDTCCQLTSGEWGCCPIPEAVCCSDHQHCCPQGYTCVAEGQCQRGSEIVAGL

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Granulin Antibody (CL5692)

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424] - Staining of human skeletal muscle shows absence of positivity in striated muscle fibers as expected (negative control).
Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424] - Staining of human prostate shows moderate granular cytoplasmic immunoreactivity in glandular cells.
Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424]

Immunohistochemistry-Paraffin: Granulin Antibody (CL5692) [NBP2-61424] - Staining of human kidney shows cytoplasmic immunoreactivity in both renal glomeruli and tubules.
View 1 more images

Applications for Granulin Antibody (CL5692)

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Granulin

Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Alternate Names

acrogranin, GEP, GP88, granulin, granulin-epithelin, granulins, PC cell-derived growth factor, PCDGF, PEPI, PGRN, Proepithelin, progranulin

Gene Symbol

GRN

Additional Granulin Products

Product Documents for Granulin Antibody (CL5692)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granulin Antibody (CL5692)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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