Granzyme B Antibody (CL10662)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-07984

Novus Biologicals, part of Bio-Techne
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NBP3-07984-100ul
NBP3-07984-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL10662

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Granzyme B Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: TRAVQPLRLPSNKAQVKPGQTCSVAGWGQTAPLGKHSHTLQEVKMTVQEDRKCESDLRHYYDSTIELCVGDPEIKKTSFKGDSGGPLVCNKVAQGIVSYGRNNGMPPRACTKVSS

Epitope

APLGKHSHTLQEVKM

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Granzyme B Antibody (CL10662)

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984] - Analysis in human lymph node and cerebral cortex tissues using NBP3-07984 antibody. Corresponding Granzyme B RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984] - Staining of human rectum shows strong cytoplasmic positivity in a subset of lymphoid cells.
Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984]

Immunohistochemistry-Paraffin: Granzyme B Antibody (CL10662) [NBP3-07984] - Staining of human cerebral cortex shows no positivity in neurons as expected.
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Applications for Granzyme B Antibody (CL10662)

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Granzyme B

Granzyme family serine proteases are stored in the granules of cytotoxic T lymphocytes and natural killer cells. Granzymes contain one S1 protease domain and are synthesized as preproproteins. Granzymes are released toward pathogen infected or transformed target cells during cellular immune reactions. Target cell entry by granzymes is through perforin channels. Granzymes trigger apoptosis by caspase-dependent and -independent mechanisms. There are five granzymes (A, B, G, H and K) in human and many more in mouse and rat.

Alternate Names

CGL-1, CGL1, CSPB, CTLA-1, CTLA1, CTSGL1, Fragmentin-2, Granzyme-2, GRB, GrzB, GZMB, HLP, SECT

Gene Symbol

GZMB

Additional Granzyme B Products

Product Documents for Granzyme B Antibody (CL10662)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granzyme B Antibody (CL10662)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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