Granzyme K Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17052

Novus Biologicals, part of Bio-Techne
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NBP3-17052-100ul
NBP3-17052-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Granzyme K Antibodies »

Product Summary for Granzyme K Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: LSKNEASKQTLEIKKFIPFSRVTSDPQSNDIMLVKLQTAAKLNKHVKMLHIRSKTSLRSGTK

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Granzyme K Antibody

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052] - Staining of human duodenum shows low expression as expected.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052] - Analysis in human lymph node and duodenum tissues using Anti-GZMK antibody. Corresponding GZMK RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052]

Immunohistochemistry-Paraffin: Granzyme K Antibody [NBP3-17052] - Staining of human lymph node shows high expression.

Applications for Granzyme K Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Granzyme K

The granzyme family of proteins belong to the larger peptidase S1 family. Granzyme A and granzyme B are serine proteases that facilitate apoptotic signaling in cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. Within the granules of activated CTLs, granzyme A and B are processed and converted to their active forms by the lysosomal cysteine protease cathepsin C. Once cleaved, these active proteases target distinct substrates for proteolysis and, thereby, mediate apoptosis through two different pathways. Granzyme H localizes to cytoplasmic granules of cytolytic T lymphocytes and is important for target cell lysis in cell-mediated immune responses. Granzyme K (GMZK), also designated granzyme-3 or NK-tryptase-2 (NK-TRYP-2), contains one peptidase S1 domain. Granzyme K is a serine protease localizing to the granules of natural killer cells and cytotoxic T lymphocytes. It is primarily expressed in thymus, lung, spleen and peripheral blood leukocytes.

Alternate Names

Fragmentin-3, Granzyme 3, Granzyme-K, GZMK, NK-Tryp-2, NK-Tryptase-2, TRYP2, Tryptase II

Gene Symbol

GZMK

Additional Granzyme K Products

Product Documents for Granzyme K Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Granzyme K Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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