H1FX Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-31980

Novus Biologicals, part of Bio-Techne
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NBP2-31980
NBP2-31980-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all H1FX Antibodies »

Product Summary for H1FX Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: ALPVTTAEGMAKKVTKAGGSAALSPSKKRKNSKKKNQPGKYSQLVVETIRRLGERNGSSLAKIYTEAKKVPWFDQQNG

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for H1FX Antibody

Immunocytochemistry/ Immunofluorescence: H1FX Antibody [NBP2-31980]

Immunocytochemistry/ Immunofluorescence: H1FX Antibody [NBP2-31980]

Immunocytochemistry/Immunofluorescence: H1FX Antibody [NBP2-31980] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleus & nucleoli. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: H1FX Antibody [NBP2-31980]

Immunohistochemistry-Paraffin: H1FX Antibody [NBP2-31980]

Immunohistochemistry-Paraffin: H1FX Antibody [NBP2-31980] - Staining of human colon shows moderate nuclear positivity in glandular cells.

Applications for H1FX Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: H1FX

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The H1FX gene encodes a H1 Histone family, member X protein that is 213 amino acids long at 22 kDA. H1 Histones are critical for condensation of nucleosome chains into higher-order structures. H1FX participates in PKA signaling, Granzyme-A pathway, histone modification, and cell cycle start of DNA replication in early S phase. H1FX is known to interact with XBP1, TOP1, RRP1B, NPM1, and DOT1L. The H1FX gene was associated with treacher collins syndrome and metastasis efficiency.

Alternate Names

H1 histone family, member X, H1X, histone H1x, MGC15959, MGC8350

Gene Symbol

H1-10

UniProt

Q92522 (Human)

Additional H1FX Products

Product Documents for H1FX Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for H1FX Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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