HB-EGF Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-14082

Novus Biologicals, part of Bio-Techne
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NBP2-14082
NBP2-14082-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HB-EGF Antibodies »

Product Summary for HB-EGF Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: IHGECKYVKELRAPSCICHPGYHGERCHGLSLPVENRLYTYDHTTI

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (80%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HB-EGF Antibody

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082] - Staining of human skeletal muscle shows moderate cytoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082] - Staining of human heart muscle shows strong cytoplasmic positivity in myocytes.
Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082]

Immunohistochemistry-Paraffin: HB-EGF Antibody [NBP2-14082] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
View 1 more images

Applications for HB-EGF Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HB-EGF

HB-EGF is an EGF related growth factor that signals through the EGF receptor, and stimulates the proliferation of smooth muscle cells (SMC), fibroblasts, epithelial cells, and keratinocytes. HB-EGF is expressed in numerous cell types and tissues, including vascular endothelial cells and SMC, macrophages, skeletal muscle, keratinocytes, and certain tumor cells. The ability of HB-EGF to specifically bind heparin and heparin sulfate proteoglycans is distinct from other EGF-like molecules, and may be related to the enhanced mitogenic activity, relative to EGF, that HB-EGF exerts on smooth muscle cells. The human HB-EGF gene encodes a 208 amino acid transmembrane protein, which can be proteolytically cleaved to produce soluble HB-EGF. Recombinant human HB-EGF is a 9.7 kDa protein containing 86 amino acid residues, corresponding to the extra-cellular EGF-like and heparin binding domains of the full length HB-EGF protein.

Long Name

Heparin Binding EGF-like Growth Factor

Alternate Names

Dtr, Dts, HBEGF, Hegfl

Gene Symbol

HBEGF

Additional HB-EGF Products

Product Documents for HB-EGF Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HB-EGF Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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