HDAC10 Antibody (SR3178)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-27754

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-27754-100ul
NBP3-27754-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Immunocytochemistry/ Immunofluorescence, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR3178

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HDAC10 Antibodies »

Product Summary for HDAC10 Antibody (SR3178)

Immunogen

A synthesized peptide derived from human HDAC10 (Uniprot #: Q969S8)

Specificity

Detects endogenous levels of HDAC10

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for HDAC10 Antibody (SR3178)

Western Blot: HDAC10 Antibody (SR3178) [NBP3-27754] -

Western Blot: HDAC10 Antibody (SR3178) [NBP3-27754] - Western blot analysis of HDAC10 expression in (1) HeLa cell lysate; (2) 3T3 cell lysate.

Immunocytochemistry/ Immunofluorescence: HDAC10 Antibody (SR3178) [NBP3-27754] -

Immunocytochemistry/ Immunofluorescence: HDAC10 Antibody (SR3178) [NBP3-27754] - Immunofluorescent analysis of Hela cells

Applications for HDAC10 Antibody (SR3178)

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

1:50-1:200

Immunoprecipitation

1:50

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HDAC10

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino-terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated mammalian RPD3) and HDAC3, all of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.

Long Name

Histone deacetylase 10

Alternate Names

EC 3.5.1.48, EC 3.5.1.62, HD10

Gene Symbol

HDAC10

Additional HDAC10 Products

Product Documents for HDAC10 Antibody (SR3178)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for HDAC10 Antibody (SR3178)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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