HDAC6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-45611

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Histone Deacetylase 6/HDAC6 Antibodies »

Product Specifications

Immunogen

Synthetic peptide mapping to the N-terminus of mouse HDAC-6.

Specificity

The antibody does not cross-react with other HDAC proteins including HDAC1, 2, 3, 4, 5, 7, and 8.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

131 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

This product is manufactured by Abcam and distributed by Novus Biologicals. (Abcam Catalog Number: ab1440)

Scientific Data Images for HDAC6 Antibody

Western Blot: HDAC6 Antibody [NBP1-45611]

Western Blot: HDAC6 Antibody [NBP1-45611]

Western Blot: HDAC6 Antibody [NBP1-45611] - Analysis of HDAC-6 expression with Jurkat cell lysate.

Applications for HDAC6 Antibody

Application
Recommended Usage

Immunohistochemistry

20 ug/mL

Western Blot

0.5 - 4 ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2), 5 mM EDTA, 0.5% BSA, 30% Glycerol

Preservative

0.01% Thimerosal

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Histone Deacetylase 6/HDAC6

In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (p300/CBP-associated factor), p300/CBP, HAT1 and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1), HDAC2 (also designated RPD3) and HDAC3-6 have been identified as histone deacetylases.

Long Name

Histone Deacetylase 6

Alternate Names

CPBHM, FLJ16239, HD6, HDAC6, JM21, PPP1R90

Entrez Gene IDs

10013 (Human); 15185 (Mouse)

Gene Symbol

HDAC6

UniProt

Q9Z2V5 (Mouse)

Additional Histone Deacetylase 6/HDAC6 Products

Product Documents for HDAC6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HDAC6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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