Hepatitis C Virus Core Antigen Antibody (B056M)

Novus Biologicals, part of Bio-Techne | Catalog # NB110-68197

Novus Biologicals, part of Bio-Techne
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NB110-68197-0.1mg
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Key Product Details

Species Reactivity

Virus

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot (Negative)

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # B056M

Concentration

0.1 mg/ml

View all Hepatitis C Virus Core Antigen Antibodies »

Product Specifications

Immunogen

Recombinant HCV core antigen, genotype 1a.

Reactivity Notes

Hepatitis C Virus

Specificity

Hepatitis C Virus (HCV) Core Antigen. Reactive with genotypes 1a and 2. (B056M)

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Hepatitis C Virus Core Antigen Antibody (B056M)

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

1:10-1:500
Application Notes
ELISA and IFA. For ELISA, use NB110-68197 as the detection antibody and NB110-68196 as the capture antibody. Does not work in Western Blot.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

10mM PBS (pH 7.2), no stabilizing proteins.

Preservative

0.1% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4°C.

Background: Hepatitis C Virus Core Antigen

The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

Alternate Names

Core protein p19, HCcAg, HCV core antigen, HCV core protein

Gene Symbol

POLY

Additional Hepatitis C Virus Core Antigen Products

Product Documents for Hepatitis C Virus Core Antigen Antibody (B056M)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Hepatitis C Virus Core Antigen Antibody (B056M)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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