HIF-3 alpha Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89977

Novus Biologicals, part of Bio-Techne
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NBP1-89977
NBP1-89977-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all HIF-3 alpha/HIF3A Antibodies »

Product Summary for HIF-3 alpha Antibody

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: SPDLRRLLGPILDGASVAATPSTPLATRHPQSPLSADLPDELPVGTENVHRLFTSGKDTEAVETDLDIAQDADALD

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HIF-3 alpha Antibody

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977] - Staining of human skin shows moderate to strong cytoplasmic and nuclear positivity in squamous epithelial cells.
Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977] - Staining of human Fallopian tube shows moderate to strong nuclear and cytoplasmic positivity in glandular cells.
Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977]

Immunohistochemistry-Paraffin: HIF-3 alpha Antibody [NBP1-89977] - Staining of human prostate shows moderate to strong cytoplasmic and nuclear positivity in smooth muscle cells.
View 1 more images

Applications for HIF-3 alpha Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HIF-3 alpha/HIF3A

Hypoxia-inducible factor (HIF) is one of the most important factors in the cellular response to hypoxia, by transcriptionally activating genes encoding proteins that mediate adaptive responses to reduced oxygen availability. HIF is a heterodimer consisting of one of three subunits, HIF1 alpha, HIF2 alpha, or HIF3 alpha. HIF target genes play critical roles in metabolism, angiogenesis, cell proliferation and cell survival. HIF3 alpha protein is one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha 3 subunit lacks the transactivation domain found in factors containing either the alpha 1 or alpha 2 subunits. HIF3 alpha may be a marker for tumor growth and angiogenesis.

Long Name

Hypoxia Inducible Factor 3 Subunit Alpha

Alternate Names

BHLHe17, HIF3A, IPAS, MOP7, PASD7

Entrez Gene IDs

64344 (Human)

Gene Symbol

HIF3A

UniProt

Q9Y2N7 (Human)

Additional HIF-3 alpha/HIF3A Products

Product Documents for HIF-3 alpha Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for HIF-3 alpha Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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