HIST1H2AC Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-42040

Novus Biologicals, part of Bio-Techne
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NBP3-42040
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.68 mg/ml

View all HIST1H2AC Antibodies »

Product Specifications

Immunogen

Immunized with recombinant Human HIST1H2AC (Uniprot#: Q93077; Ser2-Lys130 (Uniprot#: Q93077)

Clonality

Polyclonal

Host

Rabbit

Applications for HIST1H2AC Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

5-20ug/mL

Immunohistochemistry

5-20ug/mL

Western Blot

0.5-2ug/mL
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

0.01M PBS, pH7.4, 50% glycerol

Preservative

0.05% Proclin 300

Concentration

0.68 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: HIST1H2AC

Histones are nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber as they play a critical role in transcription regulation, DNA repair, DNA replication, and chromosomal stability. The HIST1H2AC gene is found in the large histone gene cluster on chromosome 6 and codes for a histone H2A type 1-c protein that is 130 amino acids long and 14 kDA. This protein lacks polyA tails but obtains palindromic termination elements. H1 proteins are essential in forming chromatin fiber and for the condensation of nucleosome chains into higher-order structured fibers. HIST1H2AC is involved in histone modification, telomere maintenance, nucleosome assembly, and signal transduction activin A signaling regulation. It interacts with other genes HIST1H4A, HIST1H4B, HIST1H4C, HIST1H4D, and HIST1H4E. Researchers have investigated its role in various diseases such as x inactivation, immunodeficiency, lupus, hemochromatosis, and riddle syndrome.

Alternate Names

dJ221C16.4, H2A/l, H2AFLmember L, histone 1, H2ac, histone cluster 1, H2ac, histone H2A type 1-C, Histone H2A/l, histone H2AC, MGC99519

Gene Symbol

H2AC6

Additional HIST1H2AC Products

Product Documents for HIST1H2AC Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for HIST1H2AC Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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