HLA DQA2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-52094

Novus Biologicals, part of Bio-Techne
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NBP1-52094
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Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all HLA DQA2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-QGLRSVGASRH corresponding to C-Terminus according to NP_064440.1, NP_002113.2.

Epitope

C-QGLRSVGASRH

Specificity

This antibody is expected to recognize: NP_064440.1 (HLA-DQA2; GeneID: 3118) and also the very similar NP_002113.2 (HLA-DQA1; GeneID:3117).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for HLA DQA2 Antibody

Western Blot: HLA DQA2 Antibody [NBP1-52094]

Western Blot: HLA DQA2 Antibody [NBP1-52094]

Western Blot: HLA DQA2 Antibody [NBP1-52094] - Analysis of HLA DQA2 in Human Bone Marrow lysate (35ug protein in RIPA buffer) using NBP1-52094 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for HLA DQA2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:32000

Western Blot

1 - 3 ug/ml
Application Notes
WB: Approx. 28 kDa band observed in human bone marrow lysates (calculated MW of 28.0 kDa band according to NP_064440.1).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: HLA DQA2

The HLA-DQA2 gene encodes a 255 amino acid long, 28 kDA HLA class II histocompatibility antigen, DQ alpha 2 chain that functions in the peptide loading of MHC class II molecules. It does so by releasing the CLIP molecule from the peptide binding site. The HLA-DQA2 gene participates in cell adhesion molecules (CAMs), antigen processing and presentation, transport of MHC II:Ii complex along Golgi to TGN, the CDC42 pathway, and in G-protein signaling in N-RAS regulation pathways. It is known to interact with genes CD4 and HLA-DQB1. HLA-DQA2 is linked to osteoarthritis, celiac disease, diabetes, asthma, thyroiditis, childhood type dermatomyositis, graft vs. host disease, narcolepsy, and lupus.

Alternate Names

DX alpha chain, DX-ALPHA, HLA class II histocompatibility antigen, DQ alpha 2 chain, HLA class II histocompatibility antigen, DQ(6) alpha chain, HLA-DQA1, HLA-DXAMHC class II DQA2, major histocompatibility complex, class II, DQ alpha 2

Gene Symbol

HLA-DQA2

UniProt

NP_064440.1 (Human)

Additional HLA DQA2 Products

Product Documents for HLA DQA2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HLA DQA2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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