HMG-CoA Reductase/HMGCR Antibody (6Y9L8)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15641

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15641-20ul
NBP3-15641-100ul
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 6Y9L8

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all HMG-CoA Reductase/HMGCR Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 400-500 of human HMG-CoA Reductase/HMGCR (P04035). IKPLVAETDTPNRATFVVGNSSLLDTSSVLVTQEPEIELPREPRPNEECLQILGNAEKGAKFLSDAEIIQLVNAKHIPAYKLETLMETHERGVSIRRQLLS

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for HMG-CoA Reductase/HMGCR Antibody (6Y9L8)

Western Blot: HMG-CoA Reductase/HMGCR Antibody (6Y9L8) [NBP3-15641]

Western Blot: HMG-CoA Reductase/HMGCR Antibody (6Y9L8) [NBP3-15641]

Western Blot: HMG-CoA Reductase/HMGCR Antibody (6Y9L8) [NBP3-15641] - Analysis of extracts of various cell lines, using HMG-CoA Reductase/HMGCR antibody (NBP3-15641) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Applications for HMG-CoA Reductase/HMGCR Antibody (6Y9L8)

Application
Recommended Usage

Western Blot

1:500 -1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 0.05% BSA, 50% glycerol, pH7.3

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: HMG-CoA Reductase/HMGCR

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Long Name

3-Hydroxy-3-Methylglutaryl-CoA Reductase

Alternate Names

HMGCR, Hydroxymethylglutaryl-CoA Reductase, LDLCQ3

Gene Symbol

HMGCR

Additional HMG-CoA Reductase/HMGCR Products

Product Documents for HMG-CoA Reductase/HMGCR Antibody (6Y9L8)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for HMG-CoA Reductase/HMGCR Antibody (6Y9L8)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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