hnRNP K Antibody (F45 P9 C7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-30893

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human, Mouse, Rat, Chicken, Rabbit

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # F45 P9 C7

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all hnRNP K Antibodies »

Product Specifications

Immunogen

Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with a synthetic peptide derived from the C-terminal of the hnRNP K protein and mouse myeloma Ag8563 cells. Sequence common in human, mouse, rat, rabbit and chicken

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for hnRNP K Antibody (F45 P9 C7)

hnRNP K Antibody (F45 P9 C7)

Immunohistochemistry: hnRNP K Antibody (F45 P9 C7) [NBP3-30893] -

Immunohistochemistry: hnRNP K Antibody (F45 P9 C7) [NBP3-30893] - Left and Center: Immunohistochemical staining of normal colon (left) and colon carcinoma (center) using hnRNP-K antibody (Cat. No. NBP3-30893).Right: Western blot using hnRNP-K antibody on Calu6 (1) and HT29 (2) cell lysates.

Applications for hnRNP K Antibody (F45 P9 C7)

Application
Recommended Usage

Immunohistochemistry-Paraffin

: 1-5 ug/ml

Western Blot

: 1-2 ug/ml
Application Notes
.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

Phosphate buffered saline

Preservative

0.08% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: hnRNP K

The hnRNP-K family of acidic nuclear proteins has been identified using a monoclonal antibody that distinguishes between quiescent and proliferating human keratinocytes. The family, which is composed of four major proteins (hnRNPs-K A, B, C and D) and their modified forms, is present in similar overall levels in quiescent and proliferating normal keratinocytes although clear differences were observed in the levels of some of the individual variants (1). hnRNP-K is an ancient RNA/DNA-binding protein that is involved in multiple processes that compose gene expression. The pleiotropic action of K protein reflects its ability to interact with different classes of factors, interactions that are regulated by extracellular signals (2). hnRNP-K has several different cellular roles including transcription, mRNA shuttling, RNA editing and translation. Several reports implicate hnRNP K having a role in tumorigenesis, for instance hnRNP K increases transcription of the oncogene c-myc and hnRNP K expression is regulated by the p53/MDM 2 pathway (3).

Alternate Names

dC-stretch binding protein, FLJ41122, heterogeneous nuclear ribonucleoprotein K, hnRNP K, transformation upregulated nuclear protein, Transformation up-regulated nuclear protein, TUNPHNRPKCSBP

Gene Symbol

HNRNPK

Additional hnRNP K Products

Product Documents for hnRNP K Antibody (F45 P9 C7)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for hnRNP K Antibody (F45 P9 C7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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