Human Activin RIIA/B Antibody

R&D Systems, part of Bio-Techne | Catalog # MAB3391

R&D Systems, part of Bio-Techne
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MAB3391
MAB3391-SP
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Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Western Blot

Cited:

ELISA Development

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 60401

View all Activin RIIA/B Antibodies »

Product Specifications

Immunogen

Mouse myeloma cell line NS0-derived recombinant human Activin RIIB
Ser19-Thr134
Accession # Q13705

Specificity

Detects human Activin RII in direct ELISA and Western blots.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Applications for Human Activin RIIA/B Antibody

Application
Recommended Usage

Western Blot

1 µg/mL
Sample: Recombinant Human Activin RIIA Fc Chimera (Catalog # 340-R2)
Recombinant Human Activin RIIB Fc Chimera (Catalog # 339-RBB)
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified from ascites

Reconstitution

Reconstitute at 0.5 mg/mL in sterile PBS. For liquid material, refer to CoA for concentration.

Reconstitution Buffer Available:
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Formulation

Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.

Shipping

Lyophilized product is shipped at ambient temperature. Liquid small pack size (-SP) is shipped with polar packs. Upon receipt, store immediately at the temperature recommended below.

Stability & Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Activin RIIA/B

Members of the TGF- beta superfamily exert their biological effects by binding to heteromeric complexes of a type I and a type II serine-threonine kinase receptor, both of which are essential for signal transduction. Activin receptor type IIB is a type II receptor that mediates multiple signals for transforming growth factor-beta (TGF-beta) family members, including Activin, Nodal, Bmp7, GDF1, GDF3, Myostatin (GDF8), and GDF11. Through alternative mRNA splicing, multiple ActR-IIB isoforms can also be generated.

Long Name

Activin Receptor IIA/B

Alternate Names

ACTRII, ACVR2

UniProt

Q13705

Additional Activin RIIA/B Products

Product Documents for Human Activin RIIA/B Antibody

Product Datasheets

Certificate of Analysis

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Note: Certificate of Analysis not available for kit components.

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Product Specific Notices for Human Activin RIIA/B Antibody

For research use only

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